Of whom it was said, That in Isaac shall thy seed be called:
a. NLT: even though God had told him, “Isaac is the son through whom your descendants will be counted.
b. NIV: even though God had said to him, “It is through Isaac that your offspring will be reckoned.
c. YLT: of whom it was said -- 'In Isaac shall a seed be called to thee;'
d. Amplified Bible Classic: Of whom it was said, Through Isaac shall your descendants be reckoned.
e. Worrell Translation: to whom it was said, “In Isaac shall your seed be called;”
1. “Of whom it was said, That in Isaac shall thy seed be called:”
a. Of [4314 * pros] [Strong: a strengthened form of 4253; a preposition of direction; forward to, i.e. toward (with the genitive case, the side of, i.e. pertaining to; with the dative case, by the side of, i.e. near to; usually with the accusative case, the place, time, occasion, or respect, which is the destination of the relation, i.e. whither or for which it is predicated):--about, according to , against, among, at, because of, before, between, (where-)by, for, X at thy house, in, for intent, nigh unto, of, which pertain to, that, to (the end that), X together, to (you) -ward, unto, with(-in). In the comparative case, it denotes essentially the same applications, namely, motion towards, accession to, or nearness at.]
b. whom [3739 * hos; including feminine he; and neuter ho] [Strong: probably a primary word (or perhaps a form of the article 3588); the relatively (sometimes demonstrative) pronoun, who, which, what, that:--one, (an-, the) other, some, that, what, which, who(-m, -se), etc.]
c. it was said [2980 * laleo] [Strong: a prolonged form of an otherwise obsolete verb; to talk, i.e. utter words:--preach, say, speak (after), talk, tell, utter.]
d. that [3754 * hoti] [Strong: neuter of 3748 as conjunction; demonstrative, that (sometimes redundant); causative, because:--as concerning that, as though, because (that), for (that), how (that), (in) that, though, why.]
e. in [1722 * en] [Strong: a primary preposition denoting (fixed) position (in place, time or state), and (by implication) instrumentality (medially or constructively), i.e. a relation of rest (intermediate between 1519 and 1537); "in," at, (up-)on, by, etc.:--about, after, against, + almost, X altogether, among, X as, at, before, between, (here-)by (+ all means), for (... sake of), + give self wholly to, (here-)in(-to, -wardly), X mightily, (because) of, (up-)on, (open-)ly, X outwardly, one, X quickly, X shortly, (speedi-)ly, X that, X there(-in, -on), through(-out), (un-)to(-ward), under, when, where(-with), while, with(-in). Often used in compounds, with substantially the same import; rarely with verbs of motion, and then not to indicate direction, except (elliptically) by a separate (and different) preposition.]
f. Isaac [2464 * of Hebrew origin (3327); Isaac (i.e. Jitschak), the son of Abraham:--Isaac.]
g. shall… be called [2564 * kaleo] [Strong: akin to the base of 2753; to "call" (properly, aloud, but used in a variety of applications, directly or otherwise):--bid, call (forth), (whose, whose sur-)name (was (called)).]
h. thy [4671 * soi] [Strong: dative case of 4771; to thee:--thee, thine own, thou, thy.]
i. seed [4690 * sperma] [Strong: from 4687; something sown, i.e. seed (including the male "sperm"); by implication, offspring; specially, a remnant (figuratively, as if kept over for planting):--issue, seed.]
1). Albert Barnes Commentary: A numerous posterity had been promised to him. It was there said expressly that this promise was not to be fulfilled through the son of Abraham, by the bondwoman Hagar, but through Isaac. Of course, it was implied that Isaac was to reach manhood, and yet notwithstanding this, and notwithstanding Abraham fully believed it, be prepared deliberately, in obedience to the divine command, to put him to death. The phrase "thy seed be called" means, that his posterity was to be named after Isaac, or was to descend only from him. The word "called" in the Scriptures is often equivalent to the verb "to be;"
2). In repeated rhema words from God, God spoke to Abraham. Speaking broadly at first then narrowing it down, God consistently told Abraham of millions of decendants, and that it would all start with Isaac.
a). Genesis 12:2 “And I will make of thee a great nation…”
b). Genesis 12:7 “…Unto thy seed will I give this land…”
c). Genesis 13:15 “For all the land which thou seest, to thee will I give it, and to thy seed for ever.”
d). Genesis 15:5 And he brought him forth abroad, and said, Look now toward heaven, and tell the stars, if thou be able to number them: and he said unto him, So shall thy seed be.